Last Date: 1st February 2024.
Membrane identity is key to cellular function, with each organelle displaying distinct identity determinants. Key interest of the
Maib lab is how changes to this lipid identity control diverse cellular functions.
The lab uses a combination of reconstitution systems together with cell biological approaches to investigate membrane
identity changes with a current focus on the formation of membrane contact sites. In this context, the regulation of
phosphoinositide conversion mechanisms by lipid kinases and phosphatases is of central interests to the lab.
This Wellcome Trust funded post will be focused on the reconstitution of phosphoinositide conversion cascades using
supported lipid bilayer systems. You will be recombinantly producing lipid kinases and phosphatases from bacteria and/or
insect cells and determine the molecular mechanisms that control their activities. Furthermore, you will develop and refine
recombinant biosensors to detect lipids and small GTPases in cells, as highlighted by a recent preprint from the lab. You will
therefore be working at the intersection between protein reconstitution and cell biology with a high potential for
collaborations.
Applicants must hold a PhD in a relevant field along with prior experience using recombinant protein expression system.
Experience using eukaryotic expression systems and supported lipid bilayers is desirable. A passion and creativity in the use
of protein reconstitution and lipid bilayer systems to address outstanding questions in cell biology is what drives our work.
We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a
competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and
development courses to support your personal and professional development.
We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions
complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research,
teaching and student experience.
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