Last Date: March 15, 2024.
The Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences (DPhW), is offering a postdoc position to investigate mechanisms determining the sensitivity of immune cells towards endogenous and pharmacological glucocorticoids. The project is financed for two years, with the option of extension to maximally five years.
Your position
Glucocorticoids belong to the most widely used drugs to treat inflammatory diseases. Resistance to endogenous and pharmacological glucocorticoids is a major problem. The proposed project investigates endogenous and exogenous substances that influence glucocorticoid sensitivity. In collaboration with rheumatologists, we will analyze steroid profiles in patients with rheumatic diseases, attempting to identify markers indicating glucocorticoid resistance. Using macrophage models, the impact of endogenous and exogenous substances on corticosteroid receptor sensitivity and cytokine production will be studied.
The successful candidate will collaborate with our senior analytical scientist to determine/analyze steroid profiles from patients with rheumatic diseases after treatment with glucocorticoids. In collaboration with rheumatologists, the candidate is expected to perform data analyses, combining steroid concentrations and clinical data.
In addition, a main part of the project includes the establishment and use of protocols with macrophages for the investigations of endogenous and exogenous substances that alter the sensitivity of glucocorticoid and mineralocorticoid receptors for their ligands. Such substances can contribute to the increasing numbers of individuals suffering from exaggerated inflammatory diseases. Thus, it is important to identify such hazardous compounds and characterize their mechanisms of action. For this purpose, mainly in vitro assays will be applied.
The successful candidate should have a PhD with solid skills in life science methods, and experience in macrophage models and inflammatory diseases. The successful candidate will be integrated in an international research environment and is expected to contribute to the activities of our group as well as to writing manuscripts and grant proposals. We employ a multi-disciplinary approach and look for a highly motivated, pro-active and interactive team player.
Your profile
- PhD in the field of Life Sciences
- Solid experience in cell biology, biochemistry and molecular biology methods
- Experience in inflammatory disease and working with macrophages
- Experience using in vitro enzyme and/or receptor assays
- Fluent communication in English, written and oral; ideally good knowledge in German
- Highly motivated, pro-active and interactive team player
We offer you
- Postdoc position (available Apr 01, 2023, or upon negotiation, for two years, with the option of extension to max. five years)
- Training into the key techniques
- International research environment
Application / Contact
Applications should include a full CV, a short motivation letter, copies of degrees and qualifications and the names/contact data of at least two referees. For general inquiries please send an email to “[email protected]”.
Deadline: March 15, 2024
Please note that we exclusively accept applications submitted through our online application portal.
Applications via email, postal services or agencies will not be considered.
